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Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing

Cotranscriptional RNA processing and surveillance factors mediate heterochromatin formation in diverse eukaryotes. In fission yeast, RNAi machinery and RNA elimination factors including the Mtl1–Red1 core and the exosome are involved in facultative heterochromatin assembly; however, the exact mechan...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Chalamcharla, Venkata R., Folco, H. Diego, Dhakshnamoorthy, Jothy, Grewal, Shiv I. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697380/
https://ncbi.nlm.nih.gov/pubmed/26631744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522127112
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