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Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing

Cotranscriptional RNA processing and surveillance factors mediate heterochromatin formation in diverse eukaryotes. In fission yeast, RNAi machinery and RNA elimination factors including the Mtl1–Red1 core and the exosome are involved in facultative heterochromatin assembly; however, the exact mechan...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chalamcharla, Venkata R., Folco, H. Diego, Dhakshnamoorthy, Jothy, Grewal, Shiv I. S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697380/
https://ncbi.nlm.nih.gov/pubmed/26631744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522127112
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