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Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides
Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating electrical activity in the heart and brain. They are gated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD), which is connected to the...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4697172/ https://ncbi.nlm.nih.gov/pubmed/26559974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.696450 |
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