Загрузка...
Selective Inhibition of Bacterial Tryptophanyl-tRNA Synthetases by Indolmycin Is Mechanism-based
Indolmycin is a natural tryptophan analog that competes with tryptophan for binding to tryptophanyl-tRNA synthetase (TrpRS) enzymes. Bacterial and eukaryotic cytosolic TrpRSs have comparable affinities for tryptophan (K(m) ∼ 2 μm), and yet only bacterial TrpRSs are inhibited by indolmycin. Despite t...
Сохранить в:
| Опубликовано в: : | J Biol Chem |
|---|---|
| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2016
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4697160/ https://ncbi.nlm.nih.gov/pubmed/26555258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.690321 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|