Tryptophanyl-tRNA Synthetase Urzyme: A MODEL TO RECAPITULATE MOLECULAR EVOLUTION AND INVESTIGATE INTRAMOLECULAR COMPLEMENTATION

We substantiate our preliminary description of the class I tryptophanyl-tRNA synthetase minimal catalytic domain with details of its construction, structure, and steady-state kinetic parameters. Generating that active fragment involved deleting 65% of the contemporary enzyme, including the anticodon...

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Autori principali: Pham, Yen, Kuhlman, Brian, Butterfoss, Glenn L., Hu, Hao, Weinreb, Violetta, Carter, Charles W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992291/
https://ncbi.nlm.nih.gov/pubmed/20864539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.136911
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