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A Novel Tryptophanyl-tRNA Synthetase Gene Confers High-Level Resistance to Indolmycin

Indolmycin, a potential antibacterial drug, competitively inhibits bacterial tryptophanyl-tRNA synthetases. An effort to identify indolmycin resistance genes led to the discovery of a gene encoding an indolmycin-resistant isoform of tryptophanyl-tRNA synthetase. Overexpression of this gene in an ind...

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Detalhes bibliográficos
Main Authors: Vecchione, James J., Sello, Jason K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737876/
https://ncbi.nlm.nih.gov/pubmed/19546369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00723-09
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