Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1): IMPLICATIONS FOR REGULATION BY GLUCOCORTICOIDS

TNF is central to inflammation and may play a role in the pathogenesis of asthma. The 3′-untranslated region of the TNF transcript contains AU-rich elements (AREs) that are targeted by the RNA-binding protein, tristetraprolin (also known as zinc finger protein 36 (ZFP36)), which is itself up-regulat...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Shah, Suharsh, Mostafa, Mahmoud M., McWhae, Andrew, Traves, Suzanne L., Newton, Robert
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2016
Предметы:
Gene Regulation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697149/
https://ncbi.nlm.nih.gov/pubmed/26546680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.697599
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