The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia

Patients with CKD suffer high rates of thrombosis, particularly after endovascular interventions, yet few options are available to improve management and reduce thrombotic risk. We recently demonstrated that indoxyl sulfate (IS) is a potent CKD-specific prothrombotic metabolite that induces tissue f...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Shivanna, Sowmya, Kolandaivelu, Kumaran, Shashar, Moshe, Belghasim, Mostafa, Al-Rabadi, Laith, Balcells, Mercedes, Zhang, Anqi, Weinberg, Janice, Francis, Jean, Pollastri, Michael P., Edelman, Elazer R., Sherr, David H., Chitalia, Vipul C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696580/
https://ncbi.nlm.nih.gov/pubmed/26019318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014121241
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