IL-6 Trans-Signaling Drives Murine Crescentic GN

The role of IL-6 signaling in renal diseases remains controversial, with data describing both anti-inflammatory and proinflammatory effects. IL-6 can act via classic signaling, engaging its two membrane receptors gp130 and IL-6 receptor (IL-6R). Alternatively, IL-6 trans-signaling requires soluble I...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Am Soc Nephrol
Main Authors: Braun, Gerald S., Nagayama, Yoshikuni, Maruta, Yuichi, Heymann, Felix, van Roeyen, Claudia R., Klinkhammer, Barbara M., Boor, Peter, Villa, Luigi, Salant, David J., Raffetseder, Ute, Rose-John, Stefan, Ostendorf, Tammo, Floege, Jürgen
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2016
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696576/
https://ncbi.nlm.nih.gov/pubmed/26041841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014111147
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