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A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data
BACKGROUND: Rare variants have gathered increasing attention as a possible alternative source of missing heritability. Since next generation sequencing technology is not yet cost-effective for large-scale genomic studies, a widely used alternative approach is imputation. However, the imputation appr...
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Publicado no: | BMC Genomics |
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Main Authors: | , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4696174/ https://ncbi.nlm.nih.gov/pubmed/26715385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-2192-y |
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