Translational control of nociception via 4E-binding protein 1

Activation of the mechanistic/mammalian target of rapamycin (mTOR) kinase in models of acute and chronic pain is strongly implicated in mediating enhanced translation and hyperalgesia. However, the molecular mechanisms by which mTOR regulates nociception remain unclear. Here we show that deletion of...

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Vydáno v:eLife
Hlavní autoři: Khoutorsky, Arkady, Bonin, Robert P, Sorge, Robert E, Gkogkas, Christos G, Pawlowski, Sophie Anne, Jafarnejad, Seyed Mehdi, Pitcher, Mark H, Alain, Tommy, Perez-Sanchez, Jimena, Salter, Eric W, Martin, Loren, Ribeiro-da-Silva, Alfredo, De Koninck, Yves, Cervero, Fernando, Mogil, Jeffrey S, Sonenberg, Nahum
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2015
Témata:
Biochemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695384/
https://ncbi.nlm.nih.gov/pubmed/26678009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12002
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