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Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

We present the crystal structure of the junction-resolving enzyme GEN1 bound to DNA at 2.5 Å resolution. The structure of the GEN1 protein reveals it to have an elaborated FEN-XPG family fold that is modified for its role in four-way junction resolution. The functional unit in the crystal is a monom...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Liu, Yijin, Freeman, Alasdair D.J., Déclais, Anne-Cécile, Wilson, Timothy J., Gartner, Anton, Lilley, David M.J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695337/
https://ncbi.nlm.nih.gov/pubmed/26686639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.042
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