Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining

Mutations in the breast cancer susceptibility 1 (BRCA1) gene are catalysts for breast and ovarian cancers. Most mutations are associated with the BRCA1 N- and C-terminal domains linked to DNA double-strand break (DSB) repair. However, little is known about the role of the intervening serine-glutamin...

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Udgivet i:Oncotarget
Main Authors: Beckta, Jason M., Dever, Seth M., Gnawali, Nisha, Khalil, Ashraf, Sule, Amrita, Golding, Sarah E., Rosenberg, Elizabeth, Narayanan, Aarthi, Kehn-Hall, Kylene, Xu, Bo, Povirk, Lawrence F., Valerie, Kristoffer
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
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Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695017/
https://ncbi.nlm.nih.gov/pubmed/26320175
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