Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

The mevalonate (MVA) pathway is often dysregulated or overexpressed in many cancers suggesting tumor dependency on this classic metabolic pathway. Statins, which target the rate-limiting enzyme of this pathway, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), are promising agents currently being ev...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pandyra, Aleksandra A., Mullen, Peter J., Goard, Carolyn A., Ericson, Elke, Sharma, Piyush, Kalkat, Manpreet, Yu, Rosemary, Pong, Janice T., Brown, Kevin R., Hart, Traver, Gebbia, Marinella, Lang, Karl S., Giaever, Guri, Nislow, Corey, Moffat, Jason, Penn, Linda Z.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694962/
https://ncbi.nlm.nih.gov/pubmed/26353928
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