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Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one

Statins are promising anticancer agents that target the mevalonate pathway. Tumor cells are sensitive to depletion of mevalonate-derived products but this activity triggers a homeostatic feedback loop that blunts statin efficacy. We showed that dipyridamole inhibits this feedback response and potent...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell Oncol
Asıl Yazarlar: Pandyra, Aleksandra, Penn, Linda Z
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905210/
https://ncbi.nlm.nih.gov/pubmed/27308369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.969133
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