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Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one
Statins are promising anticancer agents that target the mevalonate pathway. Tumor cells are sensitive to depletion of mevalonate-derived products but this activity triggers a homeostatic feedback loop that blunts statin efficacy. We showed that dipyridamole inhibits this feedback response and potent...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905210/ https://ncbi.nlm.nih.gov/pubmed/27308369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.969133 |
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