The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization

LTX-315 has been developed as an amphipathic cationic peptide that kills cancer cells. Here, we investigated the putative involvement of mitochondria in the cytotoxic action of LTX-315. Subcellular fractionation of LTX-315-treated cells, followed by mass spectrometric quantification, revealed that t...

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Vydáno v:Oncotarget
Hlavní autoři: Zhou, Heng, Forveille, Sabrina, Sauvat, Allan, Sica, Valentina, Izzo, Valentina, Durand, Sylvère, Müller, Kevin, Liu, Peng, Zitvogel, Laurence, Rekdal, Øystein, Kepp, Oliver, Kroemer, Guido
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
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Priority Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694939/
https://ncbi.nlm.nih.gov/pubmed/26378049
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