Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow

Selectin-mediated tumor cell tethering to host cells, such as vascular endothelial cells, is a critical step in the process of cancer metastasis. We recently identified sialofucosylated mucin16 (MUC16) and podocalyxin (PODXL) as the major functional E- and L-selectin ligands expressed on the surface...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget
Main Authors: Shea, Daniel J., Wirtz, Denis, Stebe, Kathleen J., Konstantopoulos, Konstantinos
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694797/
https://ncbi.nlm.nih.gov/pubmed/26329844
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items