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Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Accumulation of pathological tau protein is a major hallmark of Alzheimer’s disease. Tau protein spreads from the entorhinal cortex to the hippocampal region early in the disease. Microglia, the primary phagocytes in the brain, are positively correlated with tau pathology, but their involvement in t...
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| 發表在: | Nat Neurosci |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4694577/ https://ncbi.nlm.nih.gov/pubmed/26436904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4132 |
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