Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

BACKGROUND: Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer’s disease. Amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurodegenerative microglia (MGnD), which exhibit enhanced phagocytosis of plaques, a...

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Bibliografiske detaljer
Udgivet i:Mol Neurodegener
Main Authors: Clayton, Kevin, Delpech, Jean Christophe, Herron, Shawn, Iwahara, Naotoshi, Ericsson, Maria, Saito, Takashi, Saido, Takaomi C., Ikezu, Seiko, Ikezu, Tsuneya
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986521/
https://ncbi.nlm.nih.gov/pubmed/33752701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00440-9
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