Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

BACKGROUND: Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer’s disease. Amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurodegenerative microglia (MGnD), which exhibit enhanced phagocytosis of plaques, a...

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Dades bibliogràfiques
Publicat a:Mol Neurodegener
Autors principals: Clayton, Kevin, Delpech, Jean Christophe, Herron, Shawn, Iwahara, Naotoshi, Ericsson, Maria, Saito, Takashi, Saido, Takaomi C., Ikezu, Seiko, Ikezu, Tsuneya
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986521/
https://ncbi.nlm.nih.gov/pubmed/33752701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00440-9
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