Pharmacokinetic interaction between the CYP3A4 inhibitor ketoconazole and the hormone drospirenone in combination with ethinylestradiol or estradiol

AIMS: The present study was conducted to investigate the influence of the strong CYP3A4 inhibitor ketoconazole (KTZ) on the pharmacokinetics of drospirenone (DRSP) administered in combination with ethinylestradiol (EE) or estradiol (E2). METHODS: This was a randomized, multicentre, open label, one w...

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Foilsithe in:Br J Clin Pharmacol
Main Authors: Wiesinger, Herbert, Berse, Matthias, Klein, Stefan, Gschwend, Simone, Höchel, Joachim, Zollmann, Frank S., Schütt, Barbara
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2015
Ábhair:
Drug Interactions
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693482/
https://ncbi.nlm.nih.gov/pubmed/26271371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12745
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