The effect on sotrastaurin pharmacokinetics of strong CYP3A inhibition by ketoconazole

AIMS: Sotrastaurin is an immunosuppressant that reduces T-lymphocyte activation via protein kinase C inhibition. The effect of CYP3A4 inhibition by ketoconazole on the pharmacokinetics of sotrastaurin, a CYP3A4 substrate, was investigated. METHODS: This was a two-period, single-sequence crossover st...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kovarik, John M, Huang, Hsun-Lun A, Slade, Alan, Sfikas, Nikos, Chandler, Patricia A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766477/
https://ncbi.nlm.nih.gov/pubmed/19740395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03457.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados