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Growth hormone modulates hypothalamic inflammation in long‐lived pituitary dwarf mice
Mice in which the genes for growth hormone (GH) or GH receptor (GHR (−/−)) are disrupted from conception are dwarfs, possess low levels of IGF‐1 and insulin, have low rates of cancer and diabetes, and are extremely long‐lived. Median longevity is also increased in mice with deletion of hypothalamic...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4693470/ https://ncbi.nlm.nih.gov/pubmed/26268661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12382 |
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