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An efficient resampling method for calibrating single and gene-based rare variant association analysis in case–control studies
For aggregation tests of genes or regions, the set of included variants often have small total minor allele counts (MACs), and this is particularly true when the most deleterious sets of variants are considered. When MAC is low, commonly used asymptotic tests are not well calibrated for binary pheno...
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| 發表在: | Biostatistics |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4692986/ https://ncbi.nlm.nih.gov/pubmed/26363037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxv033 |
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