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Evaluating the calibration and power of three gene-based association tests of rare variants for the X chromosome

While genome-wide association studies (GWAS) have identified thousands of trait-associated genetic variants, there are relatively few findings on the X chromosome. For analysis of low-frequency variants (minor allele frequency < 5%), investigators can use region- or gene-based tests where multipl...

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Bibliographic Details
Published in:Genet Epidemiol
Main Authors: Ma, Clement, Boehnke, Michael, Lee, Seunggeun
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609297/
https://ncbi.nlm.nih.gov/pubmed/26454253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21935
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