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An efficient resampling method for calibrating single and gene-based rare variant association analysis in case–control studies

For aggregation tests of genes or regions, the set of included variants often have small total minor allele counts (MACs), and this is particularly true when the most deleterious sets of variants are considered. When MAC is low, commonly used asymptotic tests are not well calibrated for binary pheno...

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Detalhes bibliográficos
Publicado no:Biostatistics
Main Authors: Lee, Seunggeun, Fuchsberger, Christian, Kim, Sehee, Scott, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692986/
https://ncbi.nlm.nih.gov/pubmed/26363037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxv033
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