A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1.

Ribozymes have enormous potential as antiviral agents. We have previously reported that a hairpin ribozyme expressed under the control of the beta-actin promoter that cleaves human immunodeficiency virus type 1 (HIV-1) RNA in the leader sequence can inhibit HIV-1 (pHXB2gpt) expression. For such a ri...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Yu, M, Ojwang, J, Yamada, O, Hampel, A, Rapapport, J, Looney, D, Wong-Staal, F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46924/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8327516/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.13.6340
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