A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1.

Ribozymes have enormous potential as antiviral agents. We have previously reported that a hairpin ribozyme expressed under the control of the beta-actin promoter that cleaves human immunodeficiency virus type 1 (HIV-1) RNA in the leader sequence can inhibit HIV-1 (pHXB2gpt) expression. For such a ri...

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Autores principales: Yu, M, Ojwang, J, Yamada, O, Hampel, A, Rapapport, J, Looney, D, Wong-Staal, F
Formato: Artigo
Lenguaje:Inglês
Publicado: 1993
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC46924/
https://ncbi.nlm.nih.gov/pubmed/8327516
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