Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms

Eitemau Tebyg

• Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts
  gan: Young, David J., et al.
  Cyhoeddwyd: (2014)
• Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms
  gan: Stoddart, Angela, et al.
  Cyhoeddwyd: (2016)
• Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice
  gan: Stoddart, Angela, et al.
  Cyhoeddwyd: (2014)
• Recurrent genetic defects on chromosome 5q in myeloid neoplasms
  gan: Hosono, Naoko, et al.
  Cyhoeddwyd: (2016)
• Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders
  gan: Joslin, John M., et al.
  Cyhoeddwyd: (2007)