Systemic Delivery of an Oncolytic Adenovirus Expressing Decorin for the Treatment of Breast Cancer Bone Metastases

The development of novel therapies for breast cancer bone metastasis is a major unmet medical need. Toward that end, we have constructed an oncolytic adenovirus, Ad.dcn, and a nonreplicating adenovirus, Ad(E1-).dcn, both containing the human decorin gene. Our in vitro studies showed that Ad.dcn prod...

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Detalles Bibliográficos
Publicado en:Hum Gene Ther
Main Authors: Yang, Yuefeng, Xu, Weidong, Neill, Thomas, Hu, Zebin, Wang, Chi-Hsiung, Xiao, Xianghui, Stock, Stuart R., Guise, Theresa, Yun, Chae-Ok, Brendler, Charles B., Iozzo, Renato V., Seth, Prem
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2015
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692115/
https://ncbi.nlm.nih.gov/pubmed/26467629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2015.098
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