Ad5/48 Hexon Oncolytic Virus Expressing sTGFβRIIFc Produces Reduced Hepatic and Systemic Toxicities and Inhibits Prostate Cancer Bone Metastases

We are interested in developing oncolytic adenoviruses for the treatment of prostate cancer (PCa) bone metastases. A key limitation of Adenovirus 5 (Ad5) is that upon systemic administration, it produces major liver and systemic toxicities. To address this issue, a chimaeric Ad5/48 adenovirus mHAd.s...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Xu, Weidong, Zhang, Zhenwei, Yang, Yuefeng, Hu, Zebin, Wang, Chi-Hsiung, Morgan, Melanie, Wu, Ying, Hutten, Ryan, Xiao, Xianghui, Stock, Stuart, Guise, Theresa, Prabhakar, Bellur S, Brendler, Charles, Seth, Prem
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435591/
https://ncbi.nlm.nih.gov/pubmed/24791939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.80
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