Stem cell specific mechanisms ensure genomic fidelity within HSCs and upon aging of HSCs

Whether aged hematopoietic stem and progenitor cells (HSPCs) have impaired DNA damage repair is controversial. Using a combination of DNA mutation indicator assays, we observe a 2-3 fold increase in the number of DNA mutations in the hematopoietic system upon aging. Young and aged HSCs and HPCs do n...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Moehrle, Bettina M., Nattamai, Kalpana, Brown, Andreas, Florian, Maria C., Ryan, Marnie, Vogel, Mona, Bliederhaeuser, Corinna, Soller, Karin, Prows, Daniel R., Abdollahi, Amir, Schleimer, David, Walter, Dagmar, Milsom, Michael D., Stambrook, Peter, Porteus, Matthew, Geiger, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691560/
https://ncbi.nlm.nih.gov/pubmed/26686632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.030
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