An efficient strategy for generation of transgenic mice by lentiviral transduction of male germline stem cells in vivo

BACKGROUND: Male germline stem cells (MGSCs) are a subpopulation of germ cells in the testis tissue. MGSCs are capable of differentiation into spermatozoa and thus are perfect targets for genomic manipulation to generate transgenic animals. METHOD: The present study was to optimize a protocol of pro...

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Publicado en:J Anim Sci Biotechnol
Autores principales: Qin, Jinzhou, Xu, Haixia, Zhang, Pengfei, Zhang, Conghui, Zhu, Zhendong, Qu, Rongfeng, Qin, Yuwei, Zeng, Wenxian
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690335/
https://ncbi.nlm.nih.gov/pubmed/26705472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40104-015-0058-4
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