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The C-terminal domain of integrase binds between the two active sites
HIV integrase (HIV-IN), one of three HIV enzymes, is a target for the treatment of AIDS, but the full biological assembly has been difficult to characterize, hampering inhibitor design. The recent crystallographic structures of integrase from prototype foamy virus (PFV-IN) with bound DNA were a brea...
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| Publicado no: | J Chem Theory Comput |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4689733/ https://ncbi.nlm.nih.gov/pubmed/26575940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct501125r |
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