Iron inhibits Escherichia coli topoisomerase I activity by targeting the first two zinc-binding sites in the C-terminal domain

Escherichia coli DNA topoisomerase I (TopA) contains a 67 kDa N-terminal catalytic domain and a 30 kDa C-terminal zinc-binding region (ZD domain) which has three adjacent tetra-cysteine zinc-binding motifs. Previous studies have shown that E. coli TopA can bind both iron and zinc, and that iron bind...

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Publicado en:Protein Sci
Autores principales: Wang, Wu, Su, Xiaolu, Wang, Xiaobing, Yang, Juanjuan, Zhang, Ting, Wang, Maofeng, Wan, Rugen, Tan, Guoqiang, Lu, Jianxin
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241112/
https://ncbi.nlm.nih.gov/pubmed/25176012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2542
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