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Distinct Regions of the Escherichia coli ParC C-Terminal Domain Are Required for Substrate Discrimination by Topoisomerase IV
Type IIA DNA topoisomerases are essential enzymes that use ATP to maintain chromosome supercoiling and remove links between sister chromosomes. In Escherichia coli, the type IIA topoisomerase topo IV rapidly removes positive supercoils and catenanes from DNA but is significantly slower when confront...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3864023/ https://ncbi.nlm.nih.gov/pubmed/23867279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.04.033 |
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