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FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells

Intracellular transcriptional regulators and extracellular signaling pathways together regulate the allocation of cell fates during development, but how their molecular activities are integrated to establish the correct proportions of cells with particular fates is not known. Here we study this ques...

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Vydáno v:Development
Hlavní autoři: Schröter, Christian, Rué, Pau, Mackenzie, Jonathan Peter, Martinez Arias, Alfonso
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689219/
https://ncbi.nlm.nih.gov/pubmed/26511924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.127530
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