FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells

Intracellular transcriptional regulators and extracellular signaling pathways together regulate the allocation of cell fates during development, but how their molecular activities are integrated to establish the correct proportions of cells with particular fates is not known. Here we study this ques...

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Bibliografiske detaljer
Udgivet i:Development
Main Authors: Schröter, Christian, Rué, Pau, Mackenzie, Jonathan Peter, Martinez Arias, Alfonso
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2015
Fag:
Stem Cells and Regeneration
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689219/
https://ncbi.nlm.nih.gov/pubmed/26511924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.127530
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