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PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland
In the mammary gland, PTEN loss in luminal and basal epithelial cells results in differentiation defects and enhanced proliferation, leading to the formation of tumors with basal epithelial characteristics. In breast cancer, PTEN loss is associated with a hormone receptor-negative, basal-like subtyp...
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| Publicado no: | Dev Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4688181/ https://ncbi.nlm.nih.gov/pubmed/26526198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.10.023 |
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