VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland

The VANGL family of planar cell polarity proteins is implicated in breast cancer however its function in mammary gland biology is unknown. Here, we utilized a panel of Vang1 and Vangl2 mouse alleles to examine the requirement of VANGL family members in the murine mammary gland. We show that Vang1CKO...

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Udgivet i:Sci Rep
Main Authors: Smith, Prestina, Godde, Nathan, Rubio, Stefany, Tekeste, Melawit, Vladar, Eszter K., Axelrod, Jeffrey D., Henderson, Deborah J., Milgrom-Hoffman, Michal, Humbert, Patrick O., Hinck, Lindsay
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506599/
https://ncbi.nlm.nih.gov/pubmed/31068622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43444-8
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