Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

Many single-transmembrane proteins are sequentially cleaved by ectodomain-shedding α-secretases and the γ-secretase complex, a process called regulated intramembrane proteolysis (RIP). These cleavages are thought to be spatially and temporally separate. In contrast, we provide evidence for a hithert...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Chen, Allen C., Kim, Sumin, Shepardson, Nina, Patel, Sarvagna, Hong, Soyon, Selkoe, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687875/
https://ncbi.nlm.nih.gov/pubmed/26694839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502001
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