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Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis
Many single-transmembrane proteins are sequentially cleaved by ectodomain-shedding α-secretases and the γ-secretase complex, a process called regulated intramembrane proteolysis (RIP). These cleavages are thought to be spatially and temporally separate. In contrast, we provide evidence for a hithert...
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| Udgivet i: | J Cell Biol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687875/ https://ncbi.nlm.nih.gov/pubmed/26694839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502001 |
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