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Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
ApoE deficiency in mice (Apoe (−/−)) results in severe hypercholesterolemia and atherosclerosis. In diet-induced obesity, Apoe (−/−) display steatohepatitis but reduced accumulation of triacylglycerides and enhanced insulin sensitivity in white adipose tissue (WAT). Although the vast majority of apo...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687855/ https://ncbi.nlm.nih.gov/pubmed/26695075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145102 |
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