The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood

BACKGROUND AND PURPOSE: Stimulation of soluble guanylyl cyclase (sGC) is a valuable therapeutic strategy for the treatment of several cardiovascular diseases. The sGC stimulator riociguat has been approved for the treatment of two forms of pulmonary hypertension. Platelets contain large amounts of s...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Reiss, C., Mindukshev, I., Bischoff, V., Subramanian, H., Kehrer, L., Friebe, A., Stasch, J.‐P., Gambaryan, S., Walter, U.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687809/
https://ncbi.nlm.nih.gov/pubmed/26282717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13286
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