The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood

BACKGROUND AND PURPOSE: Stimulation of soluble guanylyl cyclase (sGC) is a valuable therapeutic strategy for the treatment of several cardiovascular diseases. The sGC stimulator riociguat has been approved for the treatment of two forms of pulmonary hypertension. Platelets contain large amounts of s...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Principais autores: Reiss, C., Mindukshev, I., Bischoff, V., Subramanian, H., Kehrer, L., Friebe, A., Stasch, J.‐P., Gambaryan, S., Walter, U.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687809/
https://ncbi.nlm.nih.gov/pubmed/26282717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13286
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