The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood

BACKGROUND AND PURPOSE: Stimulation of soluble guanylyl cyclase (sGC) is a valuable therapeutic strategy for the treatment of several cardiovascular diseases. The sGC stimulator riociguat has been approved for the treatment of two forms of pulmonary hypertension. Platelets contain large amounts of s...

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Udgivet i:Br J Pharmacol
Main Authors: Reiss, C., Mindukshev, I., Bischoff, V., Subramanian, H., Kehrer, L., Friebe, A., Stasch, J.‐P., Gambaryan, S., Walter, U.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687809/
https://ncbi.nlm.nih.gov/pubmed/26282717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13286
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