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State‐dependent blocking mechanism of K(v)1.3 channels by the antimycobacterial drug clofazimine
BACKGROUND AND PURPOSE: K(v)1.3 potassium channels are promising pharmaceutical targets for treating immune diseases as they modulate Ca(2+) signalling in T cells by regulating the membrane potential and with it the driving force for Ca(2+) influx. The antimycobacterial drug clofazimine has been dem...
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| Publicado no: | Br J Pharmacol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687807/ https://ncbi.nlm.nih.gov/pubmed/26276903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13283 |
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