Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins

BACKGROUND AND PURPOSE: Plasma protein binding (PPB) influences the free fraction of drug available to bind to its target and is therefore an important consideration in drug discovery. While traditional methods for assessing PPB (e.g. rapid equilibrium dialysis) are suitable for comparing compounds...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Blakeley, D, Sykes, D A, Ensor, P, Bertran, E, Aston, P J, Charlton, S J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687802/
https://ncbi.nlm.nih.gov/pubmed/26211929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13263
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