Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor

BACKGROUND AND PURPOSE: Kallikrein acts on high molecular weight kininogen (HK) to generate HKa (cleaved HK) and bradykinin (BK). BK exerts its effects by binding to B(2) receptors. The activation of B(2) receptors leads to the formation of tissue plasminogen activator, nitric oxide (NO) and prostac...

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Detalhes bibliográficos
Main Authors: Kolte, D, Bryant, JW, Holsworth, D, Wang, J, Akbari, P, Gibson, GW, Shariat-Madar, Z
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057299/
https://ncbi.nlm.nih.gov/pubmed/21175583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01170.x
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