Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor

BACKGROUND AND PURPOSE: Kallikrein acts on high molecular weight kininogen (HK) to generate HKa (cleaved HK) and bradykinin (BK). BK exerts its effects by binding to B(2) receptors. The activation of B(2) receptors leads to the formation of tissue plasminogen activator, nitric oxide (NO) and prostac...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kolte, D, Bryant, JW, Holsworth, D, Wang, J, Akbari, P, Gibson, GW, Shariat-Madar, Z
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2011
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057299/
https://ncbi.nlm.nih.gov/pubmed/21175583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01170.x
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