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tRNA processing defects induce replication stress and Chk2‐dependent disruption of piRNA transcription
RNase P is a conserved endonuclease that processes the 5′ trailer of tRNA precursors. We have isolated mutations in Rpp30, a subunit of RNase P, and find that these induce complete sterility in Drosophila females. Here, we show that sterility is not due to a shortage of mature tRNAs, but that atroph...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | EMBO J |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
John Wiley and Sons Inc.
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687792/ https://ncbi.nlm.nih.gov/pubmed/26471728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591006 |
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