Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies

Although humanized antibodies have been highly successful in the clinic, all current humanization techniques have potential limitations, such as: reliance on rodent hosts, immunogenicity due to high non-germ-line amino acid content, v-domain destabilization, expression and formulation issues. This s...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Townsend, Sue, Fennell, Brian J., Apgar, James R., Lambert, Matthew, McDonnell, Barry, Grant, Joanne, Wade, Jason, Franklin, Edward, Foy, Niall, Ní Shúilleabháin, Deirdre, Fields, Conor, Darmanin-Sheehan, Alfredo, King, Amy, Paulsen, Janet E., Hickling, Timothy P., Tchistiakova, Lioudmila, Cunningham, Orla, Finlay, William J. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687607/
https://ncbi.nlm.nih.gov/pubmed/26621728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510944112
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