Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody

Antibodies are an important class of biotherapeutics that offer specificity to their antigen, long half-life, effector function interaction and good manufacturability. The immunogenicity of non-human-derived antibodies, which can be a major limitation to development, has been partially overcome by h...

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Dettagli Bibliografici
Pubblicato in:MAbs
Autori principali: Apgar, James R., Mader, Michelle, Agostinelli, Rita, Benard, Susan, Bialek, Peter, Johnson, Mark, Gao, Yijie, Krebs, Mark, Owens, Jane, Parris, Kevin, St. Andre, Michael, Svenson, Kris, Morris, Carl, Tchistiakova, Lioudmila
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058614/
https://ncbi.nlm.nih.gov/pubmed/27625211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1215786
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