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Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21

EP300-interacting inhibitor of differentiation 1 (EID1) belongs to a protein family implicated in the control of transcription, differentiation, DNA repair, and chromosomal maintenance. EID1 has a very short half-life, especially in G0 cells. We discovered that EID1 contains a peptidic, modular degr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Cuiyan, Li, Xiaotong, Adelmant, Guillaume, Dobbins, Jessica, Geisen, Christoph, Oser, Matthew G., Wucherpfenning, Kai W., Marto, Jarrod A., Kaelin, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687553/
https://ncbi.nlm.nih.gov/pubmed/26631746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522006112
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