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Stonefish toxin defines an ancient branch of the perforin-like superfamily

The lethal factor in stonefish venom is stonustoxin (SNTX), a heterodimeric cytolytic protein that induces cardiovascular collapse in humans and native predators. Here, using X-ray crystallography, we make the unexpected finding that SNTX is a pore-forming member of an ancient branch of the Membrane...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ellisdon, Andrew M., Reboul, Cyril F., Panjikar, Santosh, Huynh, Kitmun, Oellig, Christine A., Winter, Kelly L., Dunstone, Michelle A., Hodgson, Wayne C., Seymour, Jamie, Dearden, Peter K., Tweten, Rodney K., Whisstock, James C., McGowan, Sheena
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687532/
https://ncbi.nlm.nih.gov/pubmed/26627714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507622112
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